abstract：:Hypericum perforatum is a medicinal plant with established antidepressant properties. The aim of this meta-analysis was to compare the efficacy and tolerability of this antidepressant with selective serotonin reuptake inhibitors (SSRIs) as a group of standard antidepressants. For this purpose, Pubmed, Embase, Scopus, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rahimi R,Nikfar S,Abdollahi M

更新日期：2009-02-01 00:00:00

abstract：:It has been reported that personality traits are related to several neurotransmitters. However, the association between personality traits and the central nervous system remains unclear. In the present study, we investigated the relationships between a polymorphism involving a variable number of tandem repeats in the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tsuchimine S,Yasui-Furukori N,Kaneda A,Saito M,Nakagami T,Sato K,Kaneko S

更新日期：2008-12-12 00:00:00

abstract：:Hyperprolactinemia is an important but neglected adverse effect of antipsychotic medication. All first generation antipsychotics and the second generation antipsychotics amisulpride and risperidone have been shown to cause marked elevation in serum prolactin levels, whereas most other second generation antipsychotics ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lu ML,Shen WW,Chen CH

更新日期：2008-12-12 00:00:00

abstract：:The use of animal models (particularly rats) in research for developing drugs for central nervous system diseases is well validated. However a range of strains are often utilised in these models. The Lister-Hooded (LH) strain is beginning to be increasingly used in preclinical investigations. Thus, the objective of th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： McDermott C,Kelly JP

更新日期：2008-12-12 00:00:00

abstract：:Neurodevelopmental factors have been implicated in the pathophysiology of mental disorders. However, the evidence regarding their role in bipolar disorder is controversial. We reviewed the pertinent literature searching for evidence regarding a neurodevelopmental origin of bipolar disorder. Findings from clinical, epi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sanches M,Keshavan MS,Brambilla P,Soares JC

更新日期：2008-10-01 00:00:00

abstract：:Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders for centuries in China. Our previous studies have demonstrated that the total flavonoids (XBXT-2) isolated from the extract of XBXT reversed behavioral alterations and serotonergic dysfunctions in chr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： An L,Zhang YZ,Yu NJ,Liu XM,Zhao N,Yuan L,Chen HX,Li YF

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Weight gain is a major side effect of antipsychotic treatment. Some atypical antipsychotic agents have profound effects on weight. Body weight is regulated by a complex system, including both peripheral and central factors. Two of the hormones that seem to play an important role in the regulation of food int...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Esen-Danaci A,Sarandöl A,Taneli F,Yurtsever F,Ozlen N

更新日期：2008-08-01 00:00:00

abstract：:Antidepressant drugs and electroconvulsive seizure (ECS)-treatment, an animal model of electroconvulsive therapy, induce neurogenesis in adult rats. Stress and high levels of corticosterone (CORT) on the contrary inhibit neurogenesis. Hippocampal neurogenesis has been described to occur in an angiogenic niche where pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ekstrand J,Hellsten J,Wennström M,Tingström A

更新日期：2008-08-01 00:00:00

abstract：:Alterations of antioxidant enzyme activities have been described in a number of psychiatric disorders including major depression. Subsequently, the present study examined the effects of different types of antidepressants (desipramine, imipramine, maprotiline and mirtazapine) in different concentrations (10(-5), 10(-6)...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schmidt AJ,Heiser P,Hemmeter UM,Krieg JC,Vedder H

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The psychostimulant khat (Catha edulis Forsk), is a herbal drug cultivated and chewed as a recreational and socializing drug in East Africa and the Arabian Peninsula for centuries. Due to increasing air transportation and the loosening of customs restrictions, it is now readily available in the Western Count...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Feyissa AM,Kelly JP

更新日期：2008-07-01 00:00:00

abstract：:The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kalueff AV,LaPorte JL,Murphy DL,Sufka K

更新日期：2008-07-01 00:00:00

abstract：:Lamotrigine is an anticonvulsant drug effective in the treatment of epilepsy and bipolar depression. Preclinical data showed that lamotrigine inhibited monoamine oxidase (MAO) activity in vitro. The aim of the study was to determine the effects of 6-weeks lamotrigine treatment on platelet MAO type B (MAO-B) activity i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Muck-Seler D,Sagud M,Mustapic M,Nedic G,Babic A,Mihaljevic Peles A,Jakovljevic M,Pivac N

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerab...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Miyaoka T,Furuya M,Yasuda H,Hayashida M,Nishida A,Inagaki T,Horiguchi J

更新日期：2008-04-01 00:00:00

abstract：:It is well known that an elevated percentage of ecstasy users also consume cocaine. Recently, it has been reported that a high frequency of heroin smokers first consumed heroin under the effects of ecstasy with the hope of reducing the stimulant effects of the latter drug. The aim of the present study was to evaluate ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Daza-Losada M,Rodríguez-Arias M,Aguilar MA,Miñarro J

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Recently, traditional herbal medicines have been reported to be effective for behavioral and psychological symptoms of dementia (BPSD). This study aims to examine the efficacy of Yi-Gan San (YGS) in the improvement of BPSD and sleep disorders in patients with dementia. METHODS:Five patients (1 male and 4 fem...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Shinno H,Inami Y,Inagaki T,Nakamura Y,Horiguchi J

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:The sensitivity of dopamine reward pathways has been implicated in the risk for various psychiatric disorders including compulsive overeating. The evidence is divided, however, about the direction of causal association. One argument is that a Reward Deficiency Syndrome is the risk factor, while others contend...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davis C,Levitan RD,Kaplan AS,Carter J,Reid C,Curtis C,Patte K,Hwang R,Kennedy JL

更新日期：2008-04-01 00:00:00

abstract：:Acceleration of blood leukocyte apoptosis in major depression has been described. The present studies have been undertaken to estimate the level of apoptosis of blood leukocytes in patients with depression and to examine the mechanisms leading to apoptosis. Blood was taken from 29 patients with depression (age 48.2+/-...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Szuster-Ciesielska A,Słotwińska M,Stachura A,Marmurowska-Michałowska H,Dubas-Slemp H,Bojarska-Junak A,Kandefer-Szerszeń M

更新日期：2008-04-01 00:00:00

abstract：:Lithium remains the treatment of choice for many patients suffering from bipolar disorder. However, long-term treatment with lithium carries the potential to cause renal and thyroid dysfunction. Lithium-induced nephropathies are characterised by deterioration of urinary concentrating ability as well as, less frequentl...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Raedler TJ,Wittke S,Jahn H,Koessler A,Mischak H,Wiedemann K

更新日期：2008-04-01 00:00:00

abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid involved in methionine metabolism. Elevated plasma Hcy concentration is a possible risk factor for vascular disease. Folate and vitamin B-12 are vitamins that are necessary for remethylization of Hcy to methionine. The methylenetetrahydrofolate reductase (MTHFR) is ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vurucu S,Demirkaya E,Kul M,Unay B,Gul D,Akin R,Gokçay E

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhang J,Shen Y,He G,Li X,Meng J,Guo S,Li H,Gu N,Feng G,He L

更新日期：2008-02-15 00:00:00

abstract：OBJECTIVE:This study aimed to clarify the relationship between the APOE alleles and depressive symptoms of older adults, considering individual characteristics and the effect of neighborhood environment. METHODS:Using a multilevel, stratified sampling strategy, 500 elders were recruited from official household records...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yen YC,Rebok GW,Yang MJ,Lung FW

更新日期：2008-02-15 00:00:00

abstract：:The present study was conducted to compare the effectiveness and tolerability of fluoxetine and sertraline in the treatment of undifferentiated somatoform disorder (USD), using the Patient Health Questionnaire (PHQ-15), which was specifically designed for assessing the severity of somatic symptoms. A randomized, 12-we...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Han C,Pae CU,Lee BH,Ko YH,Masand PS,Patkar AA,Jung IK

更新日期：2008-02-15 00:00:00

abstract：RATIONALE:The endogenous alkaloid harmane is enriched in plasma of patients with neurodegenerative or addictive disorders. As harmane affects neuronal activity and viability and because both parameters are strongly influenced by intracellular pH (pH(i)), we tested whether effects of harmane are correlated with altered ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bonnet U,Scherbaum N,Wiemann M

更新日期：2008-02-15 00:00:00

abstract：:Post-mortem studies of the human brain indicate that certain GABA(A) receptor subtypes may be differentially altered in schizophrenia. Increased binding to the total population of GABA(A) receptors using [3H]muscimol is observed in the post-mortem schizophrenic brain, yet a proportion of these receptors which bind ben...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Skilbeck KJ,O'Reilly JN,Johnston GA,Hinton T

更新日期：2008-02-15 00:00:00

abstract：:Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic var...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Masui T,Hashimoto R,Kusumi I,Suzuki K,Tanaka T,Nakagawa S,Suzuki T,Iwata N,Ozaki N,Kato T,Takeda M,Kunugi H,Koyama T

更新日期：2008-01-01 00:00:00

abstract：:Impairment in mismatch negativity (MMN) potentials is a robust finding in schizophrenia. There are few studies which examined the correlation between MMN deficits and neuropsychological performances. The purpose of this study was to investigate the relationship between deficits of tone duration MMN and various neurops...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Toyomaki A,Kusumi I,Matsuyama T,Kako Y,Ito K,Koyama T

更新日期：2008-01-01 00:00:00

abstract：:Attention-Deficit/Hyperactivity Disorder (ADHD) is the most prevalent psychiatric disorder currently afflicting children and is among the most common chronic conditions affecting school-age children. Modafinil is structurally different from the psychostimulants that are typically used to treat ADHD and has been report...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Amiri S,Mohammadi MR,Mohammadi M,Nouroozinejad GH,Kahbazi M,Akhondzadeh S

更新日期：2008-01-01 00:00:00

abstract：:Deficits in serotonergic (5-HT-ergic) neurotransmission and stressful life events have been implicated in affective disorders, and chronic variable stress (CVS) can elicit behavioral changes reminiscent of increased emotionality, anxiety and atypical depression after partial 5-HT depletion. This study examined the eff...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tõnissaar M,Mällo T,Eller M,Häidkind R,Kõiv K,Harro J

更新日期：2008-01-01 00:00:00

abstract：:The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic sys...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lee BC,Yang JW,Lee SH,Kim SH,Joe SH,Jung IK,Choi IG,Ham BJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Birth months have been shown to affect susceptibility to schizophrenia and other mental disorders, thus this factor could also affect predisposition to delinquency through biological effects on brain development and personality and/or through relative age effects at school. This study aimed to examine the re...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ohtani T,Sasaki T,Kadomoto I,Kato N,Yoshinaga C

更新日期：2008-01-01 00:00:00

abstract：:Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HM...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Narita K,Murata T,Hamada T,Takahashi T,Kosaka H,Sudo S,Mizukami K,Yoshida H,Wada Y

更新日期：2008-01-01 00:00:00

abstract：:Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with si...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kivisaari R,Lehtinen R,Autti T,Puuskari V,Jokela O,Ahveninen J,Rapeli P,Kähkönen S

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Atrophy of pyramidal hippocampal neurons and of the entire hippocampus has been reported in experimental models of depression and in depressive patients respectively. We investigated the efficacy of valproic acid (VPA) for reversing a depressive-like behaviour and a cytoskeletal alteration in the hippocampus...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ferrero AJ,Cereseto M,Sifonios LL,Reinés A,Peixoto E,Rubio MC,Wikinski S

更新日期：2007-10-01 00:00:00

abstract：:Disturbed glutamatergic neurotransmission has become recognized as a key component in the pathophysiology of schizophrenia. The change in serum/plasma glutamate with the use of antipsychotic medication has been studied and may be a possible clinical marker. In the present study, we examined plasma glutamate concentrat...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Maeshima H,Ohnuma T,Sakai Y,Shibata N,Baba H,Ihara H,Higashi M,Ohkubo T,Nozawa E,Abe S,Ichikawa A,Nakano Y,Utsumi Y,Suzuki T,Arai H

更新日期：2007-10-01 00:00:00

abstract：:Genetic differences among patients suffering from Major Depression are likely to contribute to interindividual differences in medication treatment response. Thus, the identification of gene variants affecting drug response is needed in order to be able to predict response to psychopharmacological drugs. This study ana...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tadić A,Rujescu D,Müller MJ,Kohnen R,Stassen HH,Dahmen N,Szegedi A

更新日期：2007-10-01 00:00:00

abstract：:The main goal of the present study was to evaluate binding to serotonin in the neocortex surrounding the epileptic focus of patients with mesial temporal lobe epilepsy (MTLE). Binding to 5-HT, 5-HT(1A), 5-HT(4), 5-HT(7) receptors and serotonin transporter (5-HTT) in T1-T2 gyri of 15 patients with MTLE and their correl...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rocha L,Lorigados-Pedre L,Orozco-Suárez S,Morales-Chacón L,Alonso-Vanegas M,García-Maeso I,Villeda-Hernández J,Osorio-Rico L,Estupiñán B,Quintana C

更新日期：2007-08-15 00:00:00

abstract：:The present study investigated the role of mitogen-activated protein kinase (MAPK) in orofacial neuropathic pain following chronic constriction injury of the infraorbital nerve (ION-CCI). Experiments were carried out on male Sprague-Dawley rats weighing between 200 and 230 g. The ION was separated from adhering tissue...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lim EJ,Jeon HJ,Yang GY,Lee MK,Ju JS,Han SR,Ahn DK

更新日期：2007-08-15 00:00:00

abstract：:Lamotrigine exhibits an anti-immobility effect in the modified forced swimming test, increasing swimming and climbing, behaviors that are related to serotonergic and noradrenergic effects, respectively. However, these effects could be secondary to lamotrigine blockade of Na(+) sensitive channel. Thus, this study inves...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Codagnone FT,Consoni FT,Rodrigues AL,Vital MA,Andreatini R

更新日期：2007-08-15 00:00:00

abstract：:CYP1A2 is an important inducible enzyme involved in the metabolism of antipsychotics. This study examined two functional polymorphisms in the gene as potential markers in predicting prolongation of QTc interval in patients treated with antipsychotics. QT intervals were measured by 12-lead electrocardiography (ECG) for...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tay JK,Tan CH,Chong SA,Tan EC

更新日期：2007-08-15 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is an important member of the neurotrophin family of growth factors, abundant in the brain and periphery. Researchers have reported that serum BDNF levels in drug-free depressed patients are lower than those of healthy controls, and have proposed that these low levels might ref...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yoshimura R,Mitoma M,Sugita A,Hori H,Okamoto T,Umene W,Ueda N,Nakamura J

更新日期：2007-06-30 00:00:00